Interaction Between the Transferrin Protein and Plutonium (and Thorium), What's New?

Author:

Zurita Cyril1,Tsushima Satoru23ORCID,Solari Pier Lorenzo4,Menut Denis4ORCID,Dourdain Sandrine5,Jeanson Aurélie1,Creff Gaëlle1ORCID,Den Auwer Christophe1ORCID

Affiliation:

1. Université Côte d'Azur, CNRS Institut de Chimie de Nice 06108 Nice France

2. Institute of Resource Ecology Helmholtz-Zentrum Dresden-Rossendorf (HZDR) 01328 Dresden Germany

3. Internationnal Research Frontiers Initiative, Institute of Innovative Research Tokyo Institute of Technology, Meguro 152-8550 Tokyo Japan

4. Synchrotron SOLEIL L'Orme des Merisiers 91190 Saint Aubin France

5. ICSM Université de Montpellier, CEA, CNRS, ENSCM Marcoule France

Abstract

AbstractTransferrin (Tf) is a glycoprotein that transports iron from the serum to the various organs. Several studies have highlighted that Tf can interact with metals other than Fe(III), including actinides that are chemical and radiological toxics. We propose here to report on the behavior of Th(IV) and Pu(IV) in comparison with Fe(III) upon Tf complexation. We considered UV‐Vis and IR data of the M2Tf complex (M=Fe, Th, Pu) and combined experimental EXAFS data with MD models. EXAFS data of the first M−O coordination sphere are consistent with the MD model considering 1 synergistic carbonate. Further EXAFS data analysis strongly suggests that contamination by Th/Pu colloids seems to occur upon Tf complexation, but it seems limited. SAXS data have also been recorded for all complexes and also after the addition of Deferoxamine‐B (DFOB) in the medium. The Rg values are very close for apoTf, ThTf and PuTf, but slightly larger than for holoTf. Data suggest that the structure of the protein is more ellipsoidal than spherical, with a flattened oblate form. From this data, the following order of conformation size might be considered:holoTf<M2Tf (M=Th, Pu)<apoTf<M2Tf‐DFOB (M=Fe, Th, Pu).

Funder

Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Reference53 articles.

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