Affiliation:
1. Faculty of Life Science and Technology Kunming University of Science and Technology Kunming 650504 P.R. China
2. College of Vocational and Technical Education Yunnan Normal University Kunming 650092 P.R. China
Abstract
AbstractUsing benzylamines as the C4 source of 1,4‐dihydropyridines (1,4‐DHPs), a Cu‐catalyzed oxidative [1+2+1+2] cascade cyclization for the synthesis of 1,4‐DHPs was firstly developed. A broad range of easily available N,N‐dimethyl enaminones and benzylamines are employed smoothly to provide a diverse range of 1,4‐DHPs with high efficiency. This method is performed by a one‐pot cascade C(sp3)−H bond functionalization/C(sp3)−N cleavage/cyclization strategy to form simultaneously two C(sp3)−C(sp2) bonds, two C(sp2)−N bonds, and a 1,4‐DHP ring.
Funder
Natural Science Foundation of Yunnan Province
Subject
General Chemistry,Catalysis,Organic Chemistry
Cited by
12 articles.
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