Affiliation:
1. Department of Chemistry Saint Louis University 3501 Laclede Ave St. Louis Missouri 63103 USA
Abstract
AbstractReported herein is the development of a novel method for activating thioglycosides without a glycosyl halide intermediate. This has been achieved through the use of a silver salt coupled with an acid additive and molecular iodine. The enhanced stereocontrol was achieved via the H‐bond mediated aglycone delivery (HAD) method, and the extended trisaccharide synthesis was achieved via iteration of deprotection and glycosylation steps.
Funder
National Institute of General Medical Sciences
Division of Chemistry
Subject
General Chemistry,Catalysis,Organic Chemistry