Aerobic Asymmetric Allylic C−H Alkylation by Synergistic Chiral Primary Amine‐Palladium‐Hydroquinone Catalysis

Abstract

AbstractA synergistic chiral primary amine/palladium /p‐hydroquinone catalysis was developed to facilitate oxidative asymmetric allylic C−H alkylation under aerobic conditions. The ternary synergistic catalysis enables a facile allylic C−H activation and alkylation with oxygen so that stoichiometric utilization of benzoquinone can be avoided. The identified optimal catalytic system allows for terminal addition to allyl arenes with α‐branched β‐ketocarbonyls to afford allylic adducts bearing all‐carbon quaternary centers with high regio‐ and enantioselectivity. This work provides new insights for further studies on the aerobically oxidative C−H alkylation reaction.