Affiliation:
1. CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Shandong Key Laboratory of Coastal Environmental Processes YICCAS Yantai Institute of Coastal Zone Research (YIC) Chinese Academy of Sciences (CAS) Yantai 264003 Shandong P. R. China
2. University of Chinese Academy of Sciences Beijing 100049 P. R. China
3. Qingdao National Laboratory for Marine Science and Technology Qingdao 266237 Shandong (P. R. China) Center for Ocean Mega-Science Chinese Academy of Sciences Qingdao 266071 Shandong P. R. China
Abstract
AbstractModern potentiometric sensors based on polymeric membrane ion‐selective electrodes (ISEs) have achieved new breakthroughs in sensitivity, selectivity, and stability and have extended applications in environmental surveillance, medical diagnostics, and industrial analysis. Moreover, nonclassical potentiometry shows promise for many applications and opens up new opportunities for potentiometric biosensing. Here, we aim to provide a concept to summarize advances over the past decade in the development of potentiometric biosensors with polymeric membrane ISEs. This Concept article articulates sensing mechanisms based on non‐equilibrium measurement techniques. In particular, we emphasize new trends in potentiometric biosensing based on attractive dynamic approaches. Representative examples are selected to illustrate key applications under zero‐current conditions and stimulus‐controlled modes. More importantly, fruitful information obtained from non‐equilibrium measurements with dynamic responses can be useful for artificial intelligence (AI). The combination of ISEs with advanced AI techniques for effective data processing is also discussed. We hope that this Concept will illustrate the great possibilities offered by non‐equilibrium measurement techniques and AI in potentiometric biosensing and encourage further innovations in this exciting field.
Funder
National Natural Science Foundation of China
Taishan Scholar Foundation of Shandong Province
Subject
General Chemistry,Catalysis,Organic Chemistry
Cited by
2 articles.
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