Affiliation:
1. Department of Chemistry “Ugo Schiff”, DICUS Università degli Studi di Firenze Campus Sesto 50019 Sesto Fiorentino Firenze Italy
2. Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM) Department of Chemistry “Ugo Schiff” DICUS Campus Sesto 50019 Sesto Fiorentino Firenze Italy
Abstract
AbstractThe Gal(α1‐3)Gal is the terminal disaccharide unit of the α‐Gal epitope [Gal(α1‐3)Gal(β1‐4)GlcNAc], an exogenous antigenic determinant with several clinical implications, found in all non‐primate mammals and in several dangerous pathogens, including certain protozoa and mycobacteria. Its absence in humans makes the α‐Gal epitope an interesting target for several infectious diseases. Here we present the development of a macrocyclic tweezers‐shaped receptor, resulting from the combination of the structural features of two predecessors belonging to the family of diaminocarbazole receptors, which exhibits binding properties in the low millimolar range toward the Gal(α1‐3)Gal disaccharide of the α‐Gal antigen.