Supramolecular Control of the Temperature Responsiveness of Fluorescent Macrocyclic Molecular Rotamers

Author:

Berry Stuart N.1ORCID,Zou Meijun1,Nguyen Sarah L.1,Sajowitz Aidan E.1,Qin Lei1ORCID,Lewis William12ORCID,Jolliffe Katrina A.134ORCID

Affiliation:

1. School of Chemistry The University of Sydney NSW 2006 Australia

2. Sydney Analytical The University of Sydney NSW 2006 Australia

3. The University of Sydney Nano Institute (Sydney Nano) The University of Sydney NSW 2006 Australia

4. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science The University of Sydney NSW 2006 Australia

Abstract

AbstractTo fully harness the potential of molecular machines, it is crucial to develop methods by which to exert control over their speed of motion through the application of external stimuli. A conformationally strained macrocyclic fluorescent rotamer, CarROT, displays a reproducible and linear fluorescence decrease towards temperature over the physiological temperature range. Through the external addition of anions, cations or through deprotonation, the compound can access four discreet rotational speeds via supramolecular interactions (very slow, slow, fast and very fast) which in turn stop, reduce or enhance the thermoluminescent properties due to increasing or decreasing non‐radiative decay processes, thereby providing a means to externally control the temperature sensitivity of the system. Through comparison with analogues with a higher degree of conformational freedom, the high thermosensitivity of CarROT over the physiological temperature range was determined to be due to conformational strain, which causes a high energy barrier to rotation over this range. Analogues with a higher degree of conformational freedom display lower sensitivities towards temperature over the same temperature range. This study provides an example of an information rich small molecule, in which programable rotational speed states can be observed with facile read‐out.

Funder

Australian Research Council

Publisher

Wiley

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