Intermittent versus continuous erlotinib with concomitant modified “XELOX” (q3W) in first-line treatment of metastatic colorectal cancer

Author:

Ma Brigette B. Y.1,Chan Stephen L.1,Ho Wing M.1,Lau Wilson1,Mo Frankie1,Hui Edwin P.1,Chan Charles1,Poon Annette1,Dattatray Rasalkar D.2,Wong S. C. Cesar3,To Ka F.4,King Ann D.2,Ahuja Anil2,Chan Anthony T. C.1

Affiliation:

1. Department of Clinical Oncology, Sir Y.K. Pao Centre for Cancer, State Key Laboratory in Oncology in South China, Hong Kong Cancer Institute and Li Ka Shing Institute of Health Sciences; Chinese University of Hong Kong; Hong Kong SAR China

2. Department of Imaging and Interventional Radiology; Prince of Wales Hospital; Hong Kong SAR China

3. Department of Health Technology and Informatics; the Hong Kong Polytechnic University; Hong Kong SAR China

4. Department of Anatomical and Cellular Pathology, Prince of Wales Hospital; Chinese University of Hong Kong; Hong Kong SAR China

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference36 articles.

1. Bevacizumab (Bev) with or without erlotinib as maintenance therapy, following induction first-line chemotherapy plus Bev, in patients (pts) with metastatic colorectal cancer (mCRC): Efficacy and safety results of the International GERCOR DREAM phase III trial;Tournigand;J Clin Oncol.,2012

2. Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer;Weickhardt;J Clin Oncol.,2012

3. Antitumor activity of erlotinib in combination with capecitabine in human tumor xenograft models;Ouchi;Cancer Chemother Pharmacol.,2006

4. The schedule-dependent enhanced cytotoxic activity of 7-ethyl-10-hydroxy-camptothecin (SN-38) in combination with Gefitinib (Iressa, ZD1839);Azzariti;Biochem Pharmacol.,2004

5. Characterization of sequence-dependent synergy between ZD1839 (“Iressa”) and oxaliplatin;Xu;Biochem Pharmacol.,2003

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