Natural history study of Pseudoachondroplasia: A focus on oral health

Author:

Patel Omkar1,Hashmi S. Shahrukh2ORCID,Chiquet Brett1,Hecht Jacqueline T.12

Affiliation:

1. School of Dentistry The University of Texas Health Science Center at Houston Houston Texas USA

2. Department of Pediatrics McGovern Medical School at the University of Texas Health Science Center at Houston Houston Texas USA

Abstract

AbstractBackgroundPseudoachondroplasia (PSACH) is a rare dwarfing condition characterized by short limbs and fingers, and multiple skeletal abnormalities/complications. There are few natural history studies delineating the medical problems in PSACH leaving a gap in many areas, especially oral health. Our study aimed to obtain information pertaining to oral health and other health‐related problems (pregnancy and childbirth, skeletal health, joint pain) in patients with PSACH.MethodsTo ascertain this information, an online Qualtrics survey was distributed to members of Little People of America, a support group, and through a PSACH online chatroom.ResultsNinety‐nine of 115 surveys were completed and included in the descriptive and multivariable analyses. PSACH individuals regularly sought dental care, but flossing was challenging because of short fingers. Untreated carries (5%), bleeding gums (16%) malocclusion (37%), obstructive sleep apnea (9%), and TMJ disorder (3%) occurred less frequently compared to the general population. Delivery was by Caesarean section in 100% of female respondents who delivered a baby. Bowlegs (74%), scoliosis (43%) and osteoarthritis (36%) were the most common skeletal complications. Joint pain was reported by 85% of respondents.ConclusionsThis study provides novel insights into oral health, pregnancy and childbirth while confirming previously identified skeletal complications in PSACH. Our findings suggest that oral healthcare in PSACH presents unique challenges.

Publisher

Wiley

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