The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice-Reference-Cited by-同舟云学术

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The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice

Published:2017-07-31 Issue:7 Volume:1 Page:663-674
ISSN:2471-254X
Container-title:Hepatology Communications
language:en
Short-container-title:Hepatology Communications

Author:

Haczeyni Fahrettin¹,Wang Hans¹,Barn Vanessa¹,Mridha Auvro R.¹,Yeh Matthew M.²,Haigh W. Geoffrey³,Ioannou George N.³,Choi Yun-Jung⁴,McWherter Charles A.⁴,Teoh Narcissus C.-H.¹,Farrell Geoffrey C.¹

Affiliation:

1. Liver Research Group; Australian National University Medical School at the Canberra Hospital; Canberra ACT Australia

2. Department of Pathology; University of Washington; Seattle WA

3. VA Medical Center; Department of Medicine, University of Washington; Seattle WA

4. CymaBay Therapeutics, Inc; Newark CA

Funder

CymaBay Therapeutics, Inc.,

National Health and Medical Research Council

Publisher

Wiley

Subject

Hepatology

Reference43 articles.

1. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis;Loomba;Hepatology,2012

2. NAFLD in Asia-as common and important as in the West;Farrell;Nat Rev Gastroenterol Hepatol,2013

3. Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis;Rooyen;Gastroenterology,2011

4. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications;Cusi;Gastroenterology,2012

5. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease;Min;Cell Metab,2012

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1. Seladelpar combined with complementary therapies improves fibrosis, inflammation, and liver injury in a mouse model of nonalcoholic steatohepatitis;American Journal of Physiology-Gastrointestinal and Liver Physiology;2024-02-01

2. Design and Synthesis of Novel Indole Ethylamine Derivatives as a Lipid Metabolism Regulator Targeting PPARα/CPT1 in AML12 Cells;Molecules;2023-12-19

3. The role of peroxisome proliferator‐activated receptors in the regulation of bile acid metabolism;Basic & Clinical Pharmacology & Toxicology;2023-12-15

4. Therapeutic targets for metabolic dysfunction-associated steatotic liver disease and their roles in hepatocellular carcinoma;Exploration of Digestive Diseases;2023-12-13

5. Crosstalk between Lipids and Non-Alcoholic Fatty Liver Disease;Livers;2023-11-23

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