A survey study on antibiotic prescription practices for acute asthma exacerbations: An European academy of allergy and clinical immunology task force report-Reference-Cited by-同舟云学术

A survey study on antibiotic prescription practices for acute asthma exacerbations: An European academy of allergy and clinical immunology task force report

Published:2024-03 Issue:3 Volume:14 Page:
ISSN:2045-7022
Container-title:Clinical and Translational Allergy
language:en
Short-container-title:Clinical & Translational All

Author:

Redel Anne‐Lotte¹²^ORCID,Feleszko Wojciech³^ORCID,Arcolaci Alessandra⁴,Cefaloni Francesca⁵^ORCID,Atanaskovic‐Markovic Marina⁶,Braunstahl Gert‐Jan¹²,Boccabella Cristina⁷,Bonini Matteo⁸⁹,Karavelia Aspasia¹⁰,Louwers Eefje¹¹,Mülleneisen Norbert¹²,O'Mahony Liam¹³^ORCID,Pini Laura¹⁴,Rapiejko Anna³,Shehu Esmeralda¹⁵,Sokolowska Milena¹⁶,Untersmayr Eva¹⁷^ORCID,Tramper‐Stranders Gerdien²¹⁸^ORCID,

Affiliation:

1. Department of Pulmonology Franciscus Gasthuis & Vlietland Rotterdam The Netherlands

2. Department of Pulmonology Erasmus Medical Center Rotterdam The Netherlands

3. Department of Pediatric Allergy and Pneumonology Medical University of Warsaw Warsaw Poland

4. Immunology Unit University of Verona and General Hospital Borgo Roma Hospital Verona Italy

5. Università Cattolica del Sacro Cuore Rome Italy

6. Faculty of Medicine University of Belgrade University Children's Hospital Belgrade Serbia

7. Faculty of Medicine and Surgery Respiratory Medicine Catholic University of the Sacred Heart Milan Italy

8. Department of Cardiovascular and Thoracic Sciences Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario A. Gemelli ‐ IRCCS Rome Italy

9. National Heart and Lung Institute Royal Brompton Hospital & Imperial College London London UK

10. Department of Ear‐Nose‐Throat Surgery General Hospital of Nafplio Nafplio Greece

11. General Practice Gezondheidscentrum Berkel en Rodenrijs Berkel en Rodenrijs The Netherlands

12. Asthma‐Allergiezentrum Leverkusen Leverkusen Germany

13. Department of Medicine School of Microbiology APC Microbiome Ireland National University of Ireland Cork Ireland

14. Department of Clinical and Experimental Sciences Respiratory Medicine Unit University of Brescia ASST Spedali Civili di Brescia Brescia Italy

15. Internal Medicine Department Durres Regional Hospital Durres Albania

16. Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Zürich Switzerland

17. Institute of Pathophysiology and Allergy Research Center of Pathophysiology Infectiology and Immunology Medical University of Vienna Vienna Austria

18. Department of Pediatrics Franciscus Gasthuis & Vlietland Rotterdam The Netherlands

Abstract

AbstractIntroductionGuidelines recommend treating asthma exacerbations (AAEs) with bronchodilators combined with inhaled and/or systemic corticosteroids. Indications for antibiotic prescriptions for AAEs are usually not incorporated although the literature shows antibiotics are frequently prescribed.AimTo investigate the antibiotic prescription rates in AAEs and explore the possible determining factors of those practices.MethodsA digital survey was created to determine the antibiotic prescription rates in AAEs and the influencing factors for the prescription practices. The survey was distributed among European academy of allergy and clinical immunology (EAACI) members by mass emailing and through regional/national societies in the Netherlands, Italy, Greece, and Poland. Furthermore, we retrieved local antibiotic prescription rates.ResultsIn total, 252 participants completed the survey. Respondents stated that there is a lack of guidelines to prescribe antibiotics in AAEs. The median antibiotic prescription rate in this study was 19% [IQR: 0%–40%] and was significantly different between 4 professions: paediatrics 0% [IQR: 0%–37%], pulmonologists 25% [IQR: 10%–50%], general practitioners 25% [IQR: 0%–50%], and allergologists 17% [IQR: 0%–33%]) (p = 0.046). Additional diagnostic tests were performed in 71.4% of patients before prescription and the most common antibiotic classes prescribed were macrolides (46.0%) and penicillin (42.9%). Important clinical factors for health care providers to prescribe antibiotics were colorised/purulent sputum, abnormal lung sounds during auscultation, fever, and presence of comorbidities.ConclusionIn 19% of patients with AAEs, antibiotics were prescribed in various classes with a broad range among different subspecialities. This study stresses the urgency to compose evidence‐based guidelines to aim for more rational antibiotic prescriptions for AAE.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/clt2.12345

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