Optimization of <i>N</i> ‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1-Reference-Cited by-同舟云学术

Optimization of N ‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1

Published:2022-10-13 Issue:1 Volume:18 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Wallner Olov¹,Cázares‐Körner Armando¹,Scaletti Emma Rose²,Masuyer Geoffrey²,Bekkhus Tove¹,Visnes Torkild¹³,Mamonov Kirill¹,Ortis Florian¹,Lundbäck Thomas⁴,Volkova Maria¹,Koolmeister Tobias¹,Wiita Elisée¹,Loseva Olga¹,Pandey Monica¹,Homan Evert¹,Benítez‐Buelga Carlos¹⁵,Davies Jonathan²,Scobie Martin¹⁶,Warpman Berglund Ulrika¹⁶,Kalderén Christina¹⁶,Stenmark Pål²⁷,Helleday Thomas¹⁸,Michel Maurice¹^ORCID

Affiliation:

1. Science for Life Laboratory Department of Oncology-Pathology Karolinska Institutet 171 77 Stockholm Sweden

2. Department of Biochemistry and Biophysics Stockholm University 10691 Stockholm Sweden

3. Department of Biotechnology and Nanomedicine SINTEF Industry 7465 Trondheim Norway

4. Chemical Biology Consortium Sweden (CBCS) Science for Life Laboratory Department of Medical Biochemistry and Biophysics Karolinska Institutet 171 77 Stockholm Sweden

5. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) Madrid Spain

6. Oxcia AB 113 34 Stockholm Sweden

7. Department of Experimental Medical Science Lund University 221 00 Lund Sweden

8. Sheffield Cancer Centre Department of Oncology and Metabolism University of Sheffield S10 2TN Sheffield UK

Funder

HORIZON EUROPE European Research Council

Vetenskapsrådet

Alfred Österlunds Stiftelse

Crafoordska Stiftelsen

Cancerfonden

Dr Åke Olssons Stiftelse för Haematologisk Forskning

Innovative Medicines Initiative

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202200310

Reference27 articles.

1. Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells

2. Targeting BER enzymes in cancer therapy

3. Hallmarks of Cancer: The Next Generation

4. Targeting the DNA Damage Response in Cancer

5. ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

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