Synthesis and Characterization of Telmisartan‐Derived Cell Death Modulators to Circumvent Imatinib Resistance in Chronic Myeloid Leukemia-Reference-Cited by-同舟云学术

Synthesis and Characterization of Telmisartan‐Derived Cell Death Modulators to Circumvent Imatinib Resistance in Chronic Myeloid Leukemia

Published:2020-05-06 Issue:12 Volume:15 Page:1067-1077
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Schoepf Anna M.¹,Salcher Stefan²³,Hohn Verena¹,Veider Florina¹,Obexer Petra²⁴,Gust Ronald¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry Institute of Pharmacy CMBI – Center for Molecular Biosciences InnsbruckUniversity of Innsbruck, CCB – Centrum for Chemistry and Biomedicine Innrain 80/82 6020 Innsbruck Austria

2. Tyrolean Cancer Research Institute Innrain 66 6020 Innsbruck Austria

3. Department of Internal Medicine VMedical University Innsbruck Anichstraße 35 6020 Innsbruck Austria

4. Department of Pediatrics IIMedical University Innsbruck Innrain 66 6020 Innsbruck Austria

Funder

Österreichische Forschungsförderungsgesellschaft

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000092

Reference35 articles.

1. The molecular biology of chronic myeloid leukemia

2. New Insights into the Pathophysiology of Chronic Myeloid Leukemia and Imatinib Resistance

3. Kinase-inhibitor–insensitive cancer stem cells in chronic myeloid leukemia

4. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

5. Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia

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