Unravelling the Structure of Peroxides with Antiparasitic Activity: The Relative Impact of a Trioxolane or a Tetraoxane Pharmacophore on the Overall Molecular Structure-Reference-Cited by-同舟云学术

Unravelling the Structure of Peroxides with Antiparasitic Activity: The Relative Impact of a Trioxolane or a Tetraoxane Pharmacophore on the Overall Molecular Structure

Published:2022-08 Issue:8 Volume:87 Page:
ISSN:2192-6506
Container-title:ChemPlusChem
language:en
Short-container-title:ChemPlusChem

Author:

Amado Patrícia S. M.¹²,Jesus A. J. Lopes³,Paixão José A.⁴,Fausto Rui⁵,Cristiano Maria L. S.¹²^ORCID

Affiliation:

1. Algarve Centre of Marine Sciences (CCMAR) University of Algarve (UAlg) Gambelas Campus 8005-139 Faro Portugal

2. Department of Chemistry and Pharmacy Faculty of Science and Technology University of Algarve (UAlg) Gambelas Campus 8005-139 Faro Portugal

3. CQC-IMS Faculty of Pharmacy University of Coimbra Coimbra 3004-295 Coimbra Portugal

4. CFisUC Department of Physics University of Coimbra 3004-516 Coimbra Portugal

5. CQC-IMS Department of Chemistry University of Coimbra 3004-535 Coimbra Portugal

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cplu.202200207

Reference66 articles.

1. Plasmodium falciparum Artemisinin Resistance: The Effect of Heme, Protein Damage, and Parasite Cell Stress Response

2. New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

3. Identification of an antimalarial synthetic trioxolane drug development candidate

4. Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

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