Cyclopentadienyl Molybdenum(II) Compounds Bearing Ether and Thioether Functions in the Side Chain: Synthesis, Characterization, and Cytotoxic/Cytostatic Studies

Author:

Hanzl Lukáš1ORCID,Vinklárek Jaromír1ORCID,Honzíček Jan2ORCID,Dostál Libor1ORCID,Císařová Ivana3ORCID,Šacherlová Lucie1,Eisner Aleš4ORCID,Muthná Darina5ORCID,Řezáčová Martina5ORCID

Affiliation:

1. Department of General and Inorganic Chemistry Faculty of Chemical Technology University of Pardubice Studentská 573 532 10 Pardubice Czech Republic

2. Institute Chemistry and Technology of Macromolecular Materials Faculty of Chemical Technology University of Pardubice Studentská 573 532 10 Pardubice Czech Republic

3. Department of Inorganic Chemistry Faculty of Science Charles University in Prague Hlavova 2030/8 128 43 Prague 2 Czech Republic

4. Department of Analytical Chemistry Faculty of Chemical Technology University of Pardubice Studentská 573, 532 10 Pardubice Czech Republic

5. Department of Medical Biochemistry Faculty of Medicine in Hradec Králové Charles University in Prague Šimkova 870 500 03 Hradec Králové Czech Republic

Abstract

AbstractA series of molybdenum(II) compounds [(η5‐Cp’)Mo(CO)2(L2)][BF4] (Cp’=C5H4(CH2)2SPh, C9H6(CH2)2OMe, L2=N,N‐chelating ligand) have been synthesized and characterized by spectroscopic and analytical methods including X‐ray crystallography. The in vitro assay on human leukemia cells MOLT‐4 has shown that the substitution in the π‐ligand in combination with suitable N,N‐chelating ligand can lead to species with cytotoxicity considerably higher than reported to cisplatin. Unusually high activity was observed for compounds bearing phenanthroline ligands [{η5‐C9H6(CH2)2OMe}Mo(CO)2(3,4,7,8‐Me4phen)][BF4] (IC50=0.7±0.3 μM) and [{η5‐C9H6(CH2)2OMe}Mo(CO)2(4,7‐Ph2phen)][BF4] (IC50 values 0.8±0.4 μM).

Funder

Ministry of Higher Education and Scientific Research

Publisher

Wiley

Subject

General Chemistry

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