Affiliation:
1. School of Chemistry and Materials Engineering Huainan Normal University Huainan 232001 Anhui China
2. College of Chemistry and Materials Science Sichuan Normal University Sichuan Chengdu 610066 P. R. China
3. Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis Central China Normal University Wuhan 430079 P. R. China
Abstract
AbstractA novel and efficient Ugi four‐component domino dicyclization strategy has been developed for one‐step constructing diverse 3‐(1,3,4‐oxadiazol‐2‐yl)isoindolin‐1‐ones with good yields, without the need for additional additives. This domino dicyclization process underwent three consecutive reactions including Ugi, aza‐Wittig and N‐acylation by utilizing (N‐isocyanimine)triphenylphosphorane, methyl 2‐formylbenzoate, primary amines, and carboxylic acids. The initial biological activity testing revealed that compound 5 i exhibited good antifungal activity against certain fungi and demonstrated versatile applications in the fields of pesticide chemistry.
Funder
National Natural Science Foundation of China