Acid‐catalyzed One Pot Synthesis of Thiazolo[4,5‐b]indolamines from α‐Diazoimidamides and Thioureas

Abstract

AbstractA novel synthetic method for the formation of thiazolo[4,5‐b]indol‐2‐amines from α‐diazoimidamides and mono‐substituted thioureas in the presence of a catalytic amount of boron trifluoride etherate and camphorsulfonic acid under mild conditions was demonstrated. This methodology has a wide‐ranging scope of α‐diazoimidamides and mono‐substituted thioureas, amenable for upscaling experiments and further transformation.