Inflammation, Immunology and Allergy

Author:

Haniffa Muzlifah

Abstract

Abstract The skin is the largest barrier organ in the human body. The anatomy and composition of the human skin enables it to perform its function to protect us from external environmental challenges, including ultraviolet irradiation, temperature variation, mechanical force and microbial challenge. This chapter details our understanding of the cellular components of the human skin including the immune cells that form the skin immune network in health, following perturbation and skin disease. We chart the advancement in our knowledge of the human skin through the application of a range of technological platforms from immunohistochemistry to cutting‐edge single cell and spatial omics technologies. The chapter summarises our understanding of how the skin immune network interfaces with systemic immune responses via the peripheral blood circulation and lymphatic drainage from the skin to draining lymph nodes. In addition, we address the differences between the human and mouse skin immune networks, the role of the microbiota in health and disease as well as recent concepts of inflammation that have altered our understanding of homeostasis, repair and healing and disease.

Publisher

Wiley

Reference56 articles.

1. Human Skin Is the Largest Epithelial Surface for Interaction with Microbes

2. Epidermal differentiation and keratin gene expression

3. Keratin genes, epidermal differentiation and animal models for the study of human skin diseases

4. Antigen-Presenting Cells in the Skin

5. The distribution of Langerhans cells within the human hair follicle, and some observations on its staining properties with gold chloride;Breathnach AS;J Anat,1963

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3