Affiliation:
1. Department of Chemistry Laboratory for Organic Synthesis of Functional Systems Humboldt-Universität zu Berlin Brook-Taylor-Straße 2 Berlin Germany
2. Institute of Chemistry Technische Universität Berlin Institute of Chemistry Hardenbergstr. 40 Berlin Germany
Abstract
AbstractA versatile post‐synthetic modification strategy to functionalize a high surface area microporous network (MPN‐OH) by bio‐orthogonal inverse electron‐demand Diels‐Alder (IEDDA) ligation is presented. While the polymer matrix is modified with a readily accessible norbornene isocyanate (Nor‐NCO), a series of functional units presenting the robust asymmetric 1,2,4,5‐tetrazine (Tz) allows easy functionalization of the MPN by chemoselective Nor/Tz ligation. A generic route is demonstrated, modulating the internal interfaces by introducing carboxylates, amides or amino acids as well as an oligopeptide d‐Pro‐Pro‐Glu organocatalyst. The MPN‐Pz‐Peptide construct largely retains the catalytic activity and selectivity in an enantioselective enamine catalysis, demonstrates remarkable availability in different solvents, offers heterogeneous organocatalysis in bulk and shows stability in recycling settings.
Subject
General Energy,General Materials Science,General Chemical Engineering,Environmental Chemistry
Cited by
1 articles.
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