Affiliation:
1. Institute of Clinical Medicine University of Eastern Finland Kuopio Finland
2. Department of Medicine Wellbeing Services County of Central Finland Jyväskylä Finland
3. Section of Cardiology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, Saint Boniface Hospital University of Manitoba Winnipeg Canada
4. Heart Center, Department of Cardiology Tampere University Hospital Tampere Finland
5. Faculty of Medicine and Health Technology Tampere University Tampere Finland
6. Department of Mathematics and Statistics University of Jyvaskyla Jyväskylä Finland
Abstract
AbstractBackgroundDiabetes is an established risk factor for adverse cardiovascular outcomes including mortality, but the relationship between diabetes and mortality risk in the presence of the extensive or diffuse form of coronary artery disease (CAD) is controversial.AimsWe evaluated the association between diabetes and mortality risk in patients who underwent coronary angiography using a real‐life clinical database.MethodsWe utilized the KARDIO registry, which comprised data on demographics, prevalent diseases, including diabetes status, cardiovascular risk factors, coronary angiographies, and other interventions in 79,738 patients. Hazard ratios (HRs) (95% confidence intervals [CIs]) for the association between prevalent diabetes and all‐cause mortality were estimated.ResultsDuring a median follow‐up of 5.5 years, 11,896 all‐cause deaths occurred. In analyses adjusted for age, smoking status, hypertension, family history of CAD, dyslipidaemia, urgency of intervention, body mass index, sex, and sex‐age interaction, the HR (95% CI) for mortality comparing diabetes with no diabetes was 1.44 (1.38, 1.50). Following additional adjustment for the degree of CAD (1–3 vessels disease) as confirmed by angiography, the HR (95% CI) for mortality remained similar 1.43 (1.36, 1.49). The association did not vary significantly across several relevant clinical characteristics except for a stronger association in those with a family history of CAD than those without (p = 0.034) and former smokers than nonsmokers (p = 0.046).ConclusionIn patients undergoing coronary angiography, diabetes is associated with an increased mortality risk, independent of several risk factors including the degree of CAD. The association may be modified by family history of CAD and smoking status.