Affiliation:
1. School of Pharmaceutical Sciences Chongqing University Chongqing China
2. College of Pharmacy Chongqing Medical University Chongqing China
3. Analytical and Testing Center of Chongqing University Chongqing China
Abstract
AbstractBased on the synergistic action of hydrogen bond and electrostatic interaction, provided by methacrylic acid and 2‐aminoethyl ester hydrochloride (FM2), respectively, novel molecularly imprinted polymers (SA‐MIPs) were designed to improve its selective recognition ability. Diclofenac sodium (DFC) was chosen as the template molecule of this study. The interaction and their recognition sites between two functional monomers and templates were confirmed by nuclear magnetic resonance hydrogen spectroscopy. Because of the synergistic action of hydrogen bond and electrostatic interaction, the imprinting factor (IF) of SA‐MIPs (IF = 2.26) is superior to the corresponding monofunctional monomer imprinting materials (IF = 1.52, 1.20) and the materials using two functional monomers with an only single type of interaction (IF = 1.54, 1.75). The results of selective adsorption experiments indicate that the selective recognition ability of SA‐MIPs is significantly better than that of the other four MIPs, and the difference in selectivity coefficient for methyl orange is the largest between SA‐MIPs and the MIPs only using FM2, which is about 70 times. In addition, x‐ray photoelectron spectroscopy was used to verify the interaction between SA‐MIPs and the template. This work and its explanation of the interaction mechanism at the molecular level will be helpful for the rational design of novel MIPs with higher selectivity. Besides, SA‐MIPs have good adsorption performance (37.75 mg/g) for DFC in aqueous solutions, which could be used as potential adsorption materials for the effective removal of DFC in the aquatic environment.
Funder
National Natural Science Foundation of China
Subject
Molecular Biology,Structural Biology