A stochastic mixed effects model to assess treatment effects and fluctuations in home‐measured peak expiratory flow and the association with exacerbation risk in asthma-Reference-Cited by-同舟云学术

A stochastic mixed effects model to assess treatment effects and fluctuations in home‐measured peak expiratory flow and the association with exacerbation risk in asthma

Published:2021-12-13 Issue: Volume: Page:
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst Pharmacol

Author:

Leander Jacob¹²³^ORCID,Jirstrand Mats²^ORCID,Eriksson Ulf G.¹,Palmér Robert¹

Affiliation:

1. Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D AstraZeneca Gothenburg Sweden

2. Fraunhofer‐Chalmers Centre Chalmers Science Park Gothenburg Sweden

3. Department of Mathematical Sciences Chalmers University of Technology and University of Gothenburg Gothenburg Sweden

Funder

AstraZeneca

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12748

Reference35 articles.

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3. COPDCompEx: A novel composite endpoint for COPD exacerbations to enable faster clinical development;Vogelmeier CF;Respir Med,2020

4. Development of the EXAcerbations of Chronic Obstructive Pulmonary Disease Tool (EXACT): A Patient-Reported Outcome (PRO) Measure

5. Long‐range anticorrelations and non‐Gaussian behavior of the heartbeat;Peng CK;Phys Rev Lett,1993

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