The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects

Author:

Caltabiano Stephen1ORCID,Mahar Kelly M.2,Lister Karyn3,Tenero David2,Ravindranath Ramiya4,Cizman Borut1,Cobitz Alexander R.1

Affiliation:

1. Metabolic Pathways; GlaxoSmithKline; Collegeville Pennsylvania

2. Clinical Pharmacology Modeling & Simulation; GlaxoSmithKline; Upper Merion; Pennsylvania

3. Clinical Pharmacology Science & Study Operations; GlaxoSmithKline; Collegeville Pennsylvania

4. Clinical Statistics; GlaxoSmithKline; Bangalore India

Funder

GlaxoSmithKline

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference12 articles.

1. Daprodustat, a HIF-prolyl-hydroxylase inhibitor, maintains hemoglobin levels over 24 weeks in anemic hemodialysis subjects switching from recombinant human erythropoietin;Cobitz;J Am Soc Nephrol,2016

2. Effect of gemfibrozil on the pharmacokinetics of pioglitazone;Deng;Eur J Clin Pharmacol,2005

3. Clinical pharmacokinetics of pioglitazone;Eckland;Exp Clin Endocrinol Diabetes,2000

4. Regulation of erythropoiesis by hypoxia-inducible factors;Haase;Blood Rev,2013

5. Four-week studies of oral hypoxia-inducible factor-prolyl hydroxylase inhibitor GSK1278863 for treatment of anemia;Holdstock;J Am Soc Nephrol,2016a

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