Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues-Reference-Cited by-同舟云学术

Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues

Published:2015-09-16 Issue:46 Volume:54 Page:13550-13554
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Koch Maximilian F.,Harteis Sabrina,Blank Iris D.,Pestel Galina,Tietze Lutz F.,Ochsenfeld Christian,Schneider Sabine,Sieber Stephan A.

Funder

Deutsche Forschungsgemeinschaft

VW-Stiftung and State of Lower Saxony

SFB749

CIPSM

Fonds der chemischen Industrie

Publisher

Wiley

Subject

General Chemistry,Catalysis

Reference36 articles.

1. Structure of CC-1065 (NSC-298223), a new antitumor antibiotic.

2. Structure of duocarmycin SA, a potent antitumor antibiotic.

3. CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents.

4. Fundamental Relationships between Structure, Reactivity, and Biological Activity for the Duocarmycins and CC-1065

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