1. Department of Biochemistry and Biomedical Sciences; Michael G. DeGroote Institute for Infectious Disease Research; McMaster University; 1280 Main Street West Hamilton Ontario L8S 4K1 Canada
2. School of Laboratory Medicine and Life Sciences; Wenzhou Medical University; Wenzhou Zhejiang 325035 China
3. Department of Pathology and Molecular Medicine; St Joseph's Healthcare; McMaster University; 50 Charlton Ave E, 424 Luke Wing Hamilton Ontario L8N 4A6 Canada
4. Department of Mathematics and Statistics; University of Guelph; Guelph Ontario N1G 2W1 Canada
5. Department of Medicine; McMaster University; 1280 Main St. W. Hamilton Ontario L8S 4K1 Canada