Effects of ku‐oketsu and seinetsu Kampo medicines on rosacea‐like skin symptoms induced by steroid in mice

Author:

Watanabe Natsu1,Matsunaga Wataru2ORCID,Gotoh Akinobu3

Affiliation:

1. Cell and Gene therapy Hyogo Medical University Nishinomiya Japan

2. Joint‐use Research Facilities Hyogo Medical University Nishinomiya Japan

3. Department of Education for Medical Research Base Hyogo Medical University Nishinomiya Japan

Abstract

AbstractAimRosacea is a chronic inflammatory skin disease characterized by consistent erythema, papules, pustules, telangiectasias, and recurrent hot flashes, mainly on the cheeks, nose, and forehead. Many palliative treatment options are available for this condition; currently, no radical treatment option is available. However, improvement has been observed in some cases after the use of Kampo medicine. In this study, we aimed to analyze the effects of Jumi‐Haidokuto (JHT) and a mixture of Keishi‐Bukuryo‐gan‐ka‐Yokuinin (KBY) and JHT on steroid‐induced rosacea in mice.MethodsClobetasol propionate ointment was applied to the mice for 10 days and then the mice were provided food mixed with JHT and JHT + KBY for 28 days. Subsequently, the average velocity of capillary flow, area of the purpura, histopathologic features, and fecal metabolome were investigated.ResultsRecovery of the capillary flow velocity, reduction in the area of purpura, and restoration of the epidermal features were observed in JHT‐ and JHT + KBY‐fed mice. The improvement in circulatory disturbances observed after JHT and JHT + KBY administration might have contributed to the reduction in telangiectasias and erythema. Recovery of the skin barrier system by both Kampo medicine might be the key factor of ameliorating rosacea‐like symptoms.

Publisher

Wiley

Subject

Environmental Engineering

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3