Phenylbutyrate induces apoptosis and lipid accumulations via a peroxisome proliferator-activated receptor gamma-dependent pathway

Author:

Milkevitch Matthew,Beardsley Nancy J.,Delikatny E. James

Funder

NIH

The SAIR Program at the University of Pennsylvania

Publisher

Wiley

Subject

Spectroscopy,Radiology Nuclear Medicine and imaging,Molecular Medicine

Reference47 articles.

1. Increases in NMR visible lipid and glycerophosphocholine during phenylbutyrate-induced apoptosis in human prostate cancer cells;Milkevitch;Biochimica Biophysica Acta.,2005

2. Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate;Samid;J. Clin. Invest.,1993

3. Lovastatin enhances phenylbutyrate-induced MR-visible glycerophosphocholine but not apoptosis in DU145 prostate cells;Milkevitch;Biochimica Biophysica Acta.,2007

4. A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies;Gilbert;Clin. Cancer Res.,2001

5. Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia;Gore;Clin. Cancer Res.,2002

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