Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT-HF randomized phase 2 trial

Author:

Hulot Jean-Sébastien1,Salem Joe-Elie1,Redheuil Alban1,Collet Jean-Philippe1,Varnous Shaida1,Jourdain Patrick2,Logeart Damien3,Gandjbakhch Estelle1,Bernard Claude4,Hatem Stéphane N.1,Isnard Richard1,Cluzel Philippe1,Le Feuvre Claude1,Leprince Pascal1,Hammoudi Nadjib1,Lemoine François M.4,Klatzmann David4,Vicaut Eric5,Komajda Michel1,Montalescot Gilles15,Lompré Anne-Marie1,Hajjar Roger J.6,

Affiliation:

1. Sorbonne Universités, UPMC Univ Paris 06, AP-HP, CIC Paris-Est 1421, Institute of Cardiometabolism and Nutrition (ICAN); Pitié-Salpêtrière Hospital; F-75013 Paris France

2. Centre Hospitalier Pontoise; France

3. UMR-S 942, Université Paris Diderot, DHU FIRE, Department of Cardiology, Lariboisière Hospital; Assistance Publique-Hôpitaux de Paris (AP-HP); Paris France

4. Sorbonne Universités, UPMC Univ Paris 06, AP-HP; Clinical Investigation Center for Biotherapies and Inflammation-Immunopathology-Biotherapy Department; F-75013 Paris France

5. ACTION Study Group, Unité de Recherche Clinique, Lariboisière; Paris France

6. Cardiovascular Research Center, Icahn School of Medicine at Mount Sinaï; New York NY USA

Funder

French Ministry of Health

Celladon Corporation (La Jolla, CA, USA)

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

Reference19 articles.

1. Heart disease and stroke statistics---2012 update: a report from the American Heart Association;Roger;Circulation,2012

2. EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot);Maggioni;Eur J Heart Fail,2013

3. Calcium cycling and signaling in cardiac myocytes;Bers;Annu Rev Physiol,2008

4. Altered sarcoplasmic reticulum calcium cycling---targets for heart failure therapy;Kho;Nat Rev Cardiol,2012

5. Calcium cycling in congestive heart failure;Hasenfuss;J Mol Cell Cardiol,2002

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