Prostate Cancer Cells Preferentially Home to Osteoblast-rich Areas in the Early Stages of Bone Metastasis: Evidence From In Vivo Models

Author:

Wang Ning1,Docherty Freyja E1,Brown Hannah K1,Reeves Kimberley J2,Fowles Anne CM1,Ottewell Penelope D3,Dear T Neil4,Holen Ingunn3,Croucher Peter I5,Eaton Colby L1

Affiliation:

1. The Mellanby Centre for Bone Research, Department of Human Metabolism; The University of Sheffield; Sheffield UK

2. Break Through Breast Cancer Research Unit; Paterson Institute for Cancer Research Manchester; UK

3. Department of Oncology; The University of Sheffield; Sheffield UK

4. South Australian Health and Medical Research Institute; Adelaide; South Australia Australia

5. Garvan Institute of Medical Research; Sydney; New South Wales Australia

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference55 articles.

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2. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients;Bubendorf;Hum Pathol.,2000

3. The relationship between the spleen colony-forming cell and the haemopoietic stem cell;Schofield;Blood Cells.,1978

4. The distribution of secondary growths in cancer of the breast. 1889;Paget;Cancer Metastasis Rev.,1989

5. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow;Shiozawa;J Clin Invest.,2011

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