Automated radiochemical synthesis of pharmaceutical grade [ 18 F]FLT using 3‐N‐Boc‐5′‐O‐dimethoxytrityl‐3′‐O‐nosyl‐thymidine precursor and its Sep‐Pak® purification employing selective elution from reversed phase

Author:

Mitra Arpit1,Chakraborty Avik23,Upadhye Trupti2,Tawate Megha2,Lad Sangita2,Sahu Sudeep2,Rajesh Chinagandham2,Bagul Swati2,Pawar Yogita2,Ray Mukti Kant23,Banerjee Sharmila34ORCID

Affiliation:

1. Radiopharmaceuticals Laboratory Board of Radiation and Isotope Technology Navi Mumbai India

2. Radiation Medicine Centre Bhabha Atomic Research Centre Mumbai India

3. Department of Chemical Sciences and Life Sciences Homi Bhabha National Institute Mumbai India

4. Advanced Centre for Treatment, Research and Education in Cancer Tata Memorial Centre Navi Mumbai India

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology, Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference29 articles.

1. WalshJ PadgettH.Method for preparing radiolabeled thymidine.2003.https://patents.google.com/patent/US20050131224A1/en?oq=US+2005%2F0131224A1

2. Radiosynthesis of 3′-Deoxy-3′-[18F]Fluorothymidine ([18F]FLT)

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