Phase 2 trial results with the novel neurokinin-1 receptor antagonist casopitant in combination with ondansetron and dexamethasone for the prevention of chemotherapy-induced nausea and vomiting in cancer patients receiving moderately emetogenic chemotherapy

Author:

Arpornwirat Wichit,Albert Istvan,Hansen Vincent L.,Levin Jeremey,Bandekar Rajesh R.,Grunberg Steven M.

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference13 articles.

1. Delayed nausea and vomiting continue to reduce patients' quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment;Bloechl-Daum;J Clin Oncol.,2006

2. Chemotherapy-induced nausea and vomiting: incidence and impact on patient quality of life at community oncology settings;Cohen;Support Care Cancer.,2007

3. Co-administration of ondansetron and casopitant mesylate, a novel NK-1 receptor antagonist, results in augmented anti-emetic activity in the ferret [abstract];Gagnon;Proc Am Soc Clin Oncol.,2006

4. Evaluation of the NK-1 receptor antagonist, GW679769, in cisplatin-induced acute and delayed emesis in the ferret [abstract];King;Support Care Cancer.,2005

5. Chung F, Singla N, Singla S, Grenier A, Russo M. Casopitant for preventing postoperative vomiting in patients receiving opioids: pooled data analysis [abstract]. Paper presented at: 57th Annual Meeting of the American Society of Anesthesiologists; Madrid, Spain; October 13-17, 2006. Abstract A206.

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