Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry

Author:

Boschmans Jasper1,de Bruijn Ernst2,Van Schil Paul3,Lemière Filip1

Affiliation:

1. University of Antwerp; Chemistry, Center for Proteomics; Groenenborgerlaan 171 V.417b Antwerp BE 2020 Belgium

2. University of Leuven; Lab Experimental Oncology, UZ Gasthuisberg; CDG Building, Herestraat 49 Leuven BE 3000 Belgium

3. Antwerp University Hospital; Thoracic and Vascular Surgery; Wilrijkstraat 10 Antwerp BE 2650 Belgium

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference13 articles.

1. Outcomes following isolated limb infusion for melanoma: a 14-year experience;Kroon;Ann. Surg. Oncol.,2008

2. Pharmaco-kinetics of melphalan following oral or intravenous administration in patients with malignant disease;Tattersall;Eur. J. Cancer,1978

3. Chemistry of nitrogen mustard [2-chloro-N-(2-chloroethyl)-N-methylethanamine] studied by nuclear magnetic resonance spectroscopy;Golding;J. Chem. Soc.,1987

4. NMR studies of the conjugation of mechlorethamine with glutathione;Hamill;J. Med. Chem.,1990

5. Isolated lung perfusion and related techniques for the treatment of pulmonary metastases;Van Schil;Eur. J. Cardiothorac. Surg.,2008

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