<scp>AARS</scp> Online: A collaborative database on the structure, function, and evolution of the aminoacyl‐<scp>tRNA</scp> synthetases-Reference-Cited by-同舟云学术

AARS Online: A collaborative database on the structure, function, and evolution of the aminoacyl‐tRNA synthetases

Published:2024-09-09 Issue: Volume: Page:
ISSN:1521-6543
Container-title:IUBMB Life
language:en
Short-container-title:IUBMB Life

Author:

Douglas Jordan¹²^ORCID,Cui Haissi³,Perona John J.⁴,Vargas‐Rodriguez Oscar⁵^ORCID,Tyynismaa Henna⁶,Carreño Claudia Alvarez⁷,Ling Jiqiang⁸^ORCID,Ribas de Pouplana Lluís⁹¹⁰,Yang Xiang‐Lei¹¹,Ibba Michael¹²,Becker Hubert¹³,Fischer Frédéric¹³,Sissler Marie¹³,Carter Charles W.¹⁴^ORCID,Wills Peter R.¹²

Affiliation:

1. Department of Physics University of Auckland New Zealand

2. Centre for Computational Evolution University of Auckland New Zealand

3. Department of Chemistry University of Toronto Canada

4. Department of Chemistry Portland State University Portland Oregon USA

5. Department of Molecular Biology and Biophysics University of Connecticut Storrs Connecticut USA

6. Stem Cells and Metabolism Research Program, Faculty of Medicine University of Helsinki Finland

7. Institute of Structural and Molecular Biology University College of London UK

8. Department of Cell Biology and Molecular Genetics University of Maryland College Park Maryland USA

9. Institute for Research in Biomedicine The Barcelona Institute of Science and Technology Barcelona Catalonia Spain

10. Catalan Institution for Research and Advanced Studies Barcelona Catalonia Spain

11. Department of Molecular Medicine The Scripps Research Institute La Jolla California USA

12. Biological Sciences Chapman University Orange California USA

13. Génétique Moléculaire, Génomique Microbiologique University of Strasbourg France

14. Department of Biochemistry and Biophysics University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

Abstract

AbstractThe aminoacyl‐tRNA synthetases (aaRS) are a large group of enzymes that implement the genetic code in all known biological systems. They attach amino acids to their cognate tRNAs, moonlight in various translational and non‐translational activities beyond aminoacylation, and are linked to many genetic disorders. The aaRS have a subtle ontology characterized by structural and functional idiosyncrasies that vary from organism to organism, and protein to protein. Across the tree of life, the 22 coded amino acids are handled by 16 evolutionary families of Class I aaRS and 21 families of Class II aaRS. We introduce AARS Online, an interactive Wikipedia‐like tool curated by an international consortium of field experts. This platform systematizes existing knowledge about the aaRS by showcasing a taxonomically diverse selection of aaRS sequences and structures. Through its graphical user interface, AARS Online facilitates a seamless exploration between protein sequence and structure, providing a friendly introduction to the material for non‐experts and a useful resource for experts. Curated multiple sequence alignments can be extracted for downstream analyses. Accessible at www.aars.online, AARS Online is a free resource to delve into the world of the aaRS.

Funder

Canadian Institutes of Health Research

Research Council of Finland

Natural Sciences and Engineering Research Council of Canada

Royal Society

Alfred P. Sloan Foundation

Publisher

Wiley

Link

https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1002/iub.2911

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