<b>Switchable Multicomponent Cyclization Reactions to Access Fluoroalkylated Dihydropyrimidines and Pyrimidines under <scp>Solvent‐Free</scp> Conditions</b>-Reference-Cited by-同舟云学术

Switchable Multicomponent Cyclization Reactions to Access Fluoroalkylated Dihydropyrimidines and Pyrimidines under Solvent‐Free Conditions

Published:2024-02-23 Issue:12 Volume:42 Page:1394-1398
ISSN:1001-604X
Container-title:Chinese Journal of Chemistry
language:en
Short-container-title:Chin. J. Chem.

Author:

Zuo Wanqing¹²,Zhu Zhizhen²,Cheng Yu²,Zuo Lingling²,Geng Xiao²,Li Zhifang¹,Wang Lei¹²³

Affiliation:

1. College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education Hangzhou Normal University Hangzhou Zhejiang 311121 China

2. Advanced Research Institute and School of Pharmaceutical Sciences Taizhou University Jiaojiang Zhejiang 318000 China

3. State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Shanghai 200032 China

Abstract

Comprehensive SummaryThe development of switchable solvent‐free multicomponent reactions to build high‐value‐added products is an important demand for organic synthesis. Herein, we detailed the successful implementation of a switchable strategy for the construction of diverse 4‐fluoroalkyl‐1,4‐dihydropyrimidines and 4‐fluoroalkyl‐pyrimidines via a solvent/additive‐free [3 + 2 + 1] annulation, starting from readily available enamines, trifluoroacetaldehyde hydrate or 1‐ethoxy‐2,2‐difluoroethanol and amidines hydrochloride. This reaction conforms to the concept of green synthesis, and provides a new avenue to access valuable fluorinated heterocycles.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cjoc.202300725

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