Preparation of Novel Pyrrolo[2,3‐b]pyridine Derivatives via a New Concise Synthetic Approach

Abstract

The pyrrolo[2,3‐b]pyridine core structure, a bioisostere of quinolones, is found in several molecules that possess important biological activity. We describe here a new, concise, three‐step synthesis of pyrrolo[2,3‐b]pyridines starting from L‐alanine. A series of 4,7‐dihydro‐4‐oxo‐1H‐pyrrolo[2,3‐b]pyridine‐5‐carboxylic acid derivatives, which have not been previously reported, were synthesized using this approach.