Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats-Reference-Cited by-同舟云学术

Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats

Published:2021-10 Issue:5 Volume:9 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Wang Shuyao¹,Chen Chun¹,Guan Chi¹,Qiu Liping¹,Zhang Lei¹,Zhang Shaofeng¹,Zhou Hongyu¹,Du Hongwen¹,Li Chen¹,Wu Yaqiong¹,Chang Hang¹,Wang Tao¹^ORCID

Affiliation:

1. DMPK Department Pharmaron Inc. Beijing China

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.879

Reference51 articles.

1. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

2. Tissue Distribution and Pharmacodynamics: A Complicated Relationship

3. Intracellular and Intraorgan Concentrations of Small Molecule Drugs: Theory, Uncertainties in Infectious Diseases and Oncology, and Promise

4. On The Rate and Extent of Drug Delivery to the Brain

5. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities

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