Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human-Reference-Cited by-同舟云学术

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Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human

Published:2019-01-24 Issue:5 Volume:59 Page:731-747
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharmacology

Author:

Wong Yin Cheong¹^ORCID,Centanni Maddalena¹,Lange Elizabeth C. M.¹

Affiliation:

1. Division of Systems Biomedicine and PharmacologyLeiden Academic Center for Drug ResearchLeiden University Leiden The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.1365

Reference109 articles.

1. Target Engagement in Lead Generation

2. Target site occupancy: Emerging generalizations from clinical and preclinical studies

3. Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling—A New Classification of Biomarkers

4. Dopamine D 2 receptor occupancy predicts catalepsy and the suppression of conditioned avoidance response behavior in rats

5. Dopamine D2 Receptor Occupancy Is a Common Mechanism Underlying Animal Models of Antipsychotics and Their Clinical Effects

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