Affiliation:
1. Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Fujian Medical University Fuzhou China
2. Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health Fujian Medical University Fujian China
3. Key Laboratory of Ministry of Education for Gastrointestinal Cancer Fujian Medical University Fujian China
4. Laboratory Center The Major Subject of Environment and Health of Fujian Key Universities, School of Public Health, Fujian Medical University Fujian China
Abstract
AbstractBackgroundTo assess the prognostic role of gamma‐glutamyl transpeptidase to lymphocyte count ratio (GLR) and develop a prognostic nomogram for patients with oral cancer.MethodsA prospective cohort (n = 1011) was conducted during July 2002 to March 2021 in Southeastern China.ResultsThe median follow‐up time was 3.5 years. Multivariate Cox regression (OS: HR = 1.51, 95% CI: 1.04, 2.18) and Fine–Gray model (DSS: HR = 1.68, 95% CI: 1.14, 2.49) both showed that high GLR could act as an indicator of poor prognosis. A nonlinear dose–response relationship was observed between continuous GLR and the risk of all‐cause mortality (p for overall = 0.028, p for nonlinear = 0.048). Compare with TNM stage, time‐dependent ROC curve proved that GLR‐based nomogram model performs better in predicting prognosis (the area under curve for 1‐, 3‐, and 5‐years mortality: 0.63, 0.65, and 0.64 vs. 0.76, 0.77, and 0.78, p < 0.001).ConclusionGLR might be a useful tool in predicting prognosis for patients with oral cancer.