Inhibition of UDP-glucosylceramide synthase in mice prevents Gaucher disease-associated B-cell malignancy

Author:

Pavlova Elena V1,Archer Joy2,Z Wang Susan1,Dekker Nick3,Aerts Johannes MFG3,Karlsson Stefan4,Cox Timothy M1

Affiliation:

1. Department of Medicine; University of Cambridge; Cambridge UK

2. Department of Veterinary Medicine; University of Cambridge; Cambridge UK

3. Academic Medical Centre; Amsterdam The Netherlands

4. Lund Stem Cell Centre; Lund University Hospital; Sweden

Funder

European Union, 7th Framework Programme ‘Euclyd—a European Consortium for Lysosomal Storage Diseases’, Health F2/2008

The Cambridge Comprehensive Biomedical Research Centre of the National Institute of Health Research

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference60 articles.

1. Ries LAG Harkins D Krapcho M et al. SEER Cancer Statistics Review 1975-2003 National Cancer Institute Bethesda, MD http://seer.cancer.gov/csr/1975_2003/

2. Increased incidence of cancer in adult Gaucher disease in western Europe;Fost;Blood Cells Mol Dis,2006

3. The underrecognized progressive nature of N370S Gaucher disease and assessment of cancer risk in 403 patients;Taddei;Am J Hematol,2009

4. Gaucher disease and cancer incidence: a study from the Gaucher Registry;Rosenbloom;Blood,2005

5. Nonsecretory IgD-kappa multiple myeloma in a patient with Gaucher's disease;Benjamin;Scand J Haematol,1979

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