Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro - amitriptyline and verapamil as model compounds-Reference-Cited by-同舟云学术

Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro - amitriptyline and verapamil as model compounds

Published:2010-03-08 Issue:7 Volume:24 Page:939-957
ISSN:0951-4198
Container-title:Rapid Communications in Mass Spectrometry
language:en
Short-container-title:Rapid Commun. Mass Spectrom.

Author:

Rousu Timo,Herttuainen Jukka,Tolonen Ari

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/rcm.4465/fullpdf

Reference35 articles.

1. Prediction of Drug Metabolism and Interactions on the Basis of in vitro Investigations

2. Metabolism: A Bottleneck in In Vitro Toxicological Test Development

3. Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

4. A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

5. FDA Guidance for Industry Safety Testing of Drug Metabolites 2008 http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/GGuidance/ucm079266.pdf

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