A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation-Reference-Cited by-同舟云学术

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation

Published:2018-01-05 Issue:5 Volume:130 Page:1296-1299
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angew. Chem.

Author:

Lohans Christopher T.¹^ORCID,van Groesen Emma¹,Kumar Kiran¹^ORCID,Tooke Catherine L.²^ORCID,Spencer James²,Paton Robert S.¹,Brem Jürgen¹^ORCID,Schofield Christopher J.¹^ORCID

Affiliation:

1. Department of Chemistry; University of Oxford; Oxford OX1 3TA UK

2. School of Cellular and Molecular Medicine; University of Bristol; Bristol BS8 1TD UK

Funder

Medical Research Council

Wellcome Trust

Publisher

Wiley

Subject

General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/ange.201711308/fullpdf

Reference23 articles.

1. Carbapenemases: the Versatile β-Lactamases

2. “Stormy waters ahead”: global emergence of carbapenemases

3. Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance

4. Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A β-Lactamases from the Antibiotic-Resistant Bacteria

5. Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii

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3. Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d -Transpeptidases and Serine β-Lactamase Cysteine Variants;Angewandte Chemie International Edition;2019-01-21

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