19F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis-Reference-Cited by-同舟云学术

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19F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis

Published:2016-01-28 Issue:10 Volume:128 Page:3379-3383
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angew. Chem.

Author:

Jin Yi¹^ORCID,Molt Robert W.²,Waltho Jonathan P.¹³,Richards Nigel G. J.²⁴,Blackburn G. Michael¹

Affiliation:

1. Krebs Institute, Department of Molecular Biology and Biotechnology; University of Sheffield; Sheffield S10 2TN UK

2. Department of Chemistry and Chemical Biology; Indiana University Purdue University Indianapolis; Indianapolis IN 46202 USA

3. Manchester Institute of Biotechnology; Manchester M1 7DN UK

4. School of Chemistry; Cardiff University; Cardiff CF10 3AT UK

Funder

BBSRC UK

Publisher

Wiley

Subject

General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/ange.201509477/fullpdf

Reference45 articles.

1. Crystallographic Evidence for Substrate-Assisted GTP Hydrolysis by a Small GTP Binding Protein

2. Ras Superfamily Small G Proteins: Biology and Mechanisms 2

3. Regulation of Small GTPases by GEFs, GAPs, and GDIs

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1. Mechanism-Based Redesign of GAP to Activate Oncogenic Ras;Journal of the American Chemical Society;2023-09-08

2. An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition;ACS Catalysis;2022-02-22

3. A GAP‐GTPase‐GDP‐P i Intermediate Crystal Structure Analyzed by DFT Shows GTP Hydrolysis Involves Serial Proton Transfers;Chemistry – A European Journal;2019-05-27

4. Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with 19 F Magnetic Resonance;European Journal of Organic Chemistry;2017-08-15

5. Assessing the Influence of Mutation on GTPase Transition States by Using X‐ray Crystallography, 19 F NMR, and DFT Approaches;Angewandte Chemie International Edition;2017-08-07

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