Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores

Author:

Ishorst Nina1ORCID,Henschel Leonie1,Thieme Frederic1ORCID,Drichel Dmitriy2,Sivalingam Sugirthan345,Mehrem Sarah L.1,Fechtner Ariane C.1,Fazaal Julia1,Welzenbach Julia1,Heimbach André1,Maj Carlo4,Borisov Oleg4,Hausen Jonas345,Raff Ruth1,Hoischen Alexander678ORCID,Dixon Michael9,Rada‐Iglesias Alvaro10,Bartusel Michaela1112ORCID,Rojas‐Martinez Augusto1314ORCID,Aldhorae Khalid1516,Braumann Bert17,Kruse Teresa17,Kirschneck Christian18ORCID,Spanier Gerrit19ORCID,Reutter Heiko120,Nowak Stefanie1,Gölz Lina2122,Knapp Michael5,Buness Andreas345ORCID,Krawitz Peter4,Nöthen Markus M.1,Nothnagel Michael223ORCID,Becker Tim24,Ludwig Kerstin U.1ORCID,Mangold Elisabeth1ORCID

Affiliation:

1. Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn Bonn Germany

2. Cologne Center for Genomics University of Cologne Cologne Germany

3. Core Unit for Bioinformatic Analysis, Medical Faculty University of Bonn Bonn Germany

4. Institute for Genomic Statistics and Bioinformatics, University of Bonn School of Medicine & University Hospital Bonn Bonn Germany

5. Institute of Medical Biometry, Informatics and Epidemiology University Hospital Bonn Bonn Germany

6. Department of Human Genetics Radboud University Medical Center Nijmegen The Netherlands

7. Department of Internal Medicine Radboud University Medical Center Nijmegen The Netherlands

8. Radboud Institute for Molecular Life Sciences Radboud University Medical Center Nijmegen The Netherlands

9. Faculty of Biology, Medicine & Health University of Manchester Manchester UK

10. Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC) CSIC/University of Cantabria Santander Spain

11. Center for Molecular Medicine Cologne (CMMC) University of Cologne Cologne Germany

12. Department of Biology Massachusetts Institute of Technology Cambridge Massachusetts USA

13. Tecnologico de Monterrey Escuela de Medicina y Ciencias de la Salud Monterrey Mexico

14. Centro de Investigacion y Desarrollo en Ciencias de la Salud Universidad Autonoma de Nuevo Leon Monterrey Mexico

15. Department of Orthodontics, College of Dentistry Thamar University Thamar Yemen

16. Department of Orthodontics, College of Dentistry University of Ibn al‐Nafis for Medical Sciences Sanaa Yemen

17. Faculty of Medicine and University Hospital Cologne, Department of Orthodontics University of Cologne Cologne Germany

18. Department of Orthodontics University of Regensburg Regensburg Germany

19. Department of Cranio‐Maxillofacial Surgery University Hospital Regensburg Regensburg Germany

20. Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics and Adolescent Medicine University Hospital Erlangen Erlangen Germany

21. Department of Orthodontics University of Erlangen‐Nürnberg Erlangen Germany

22. Department of Orthodontics University of Bonn Bonn Germany

23. University Hospital Cologne Cologne Germany

24. Institute of Community Medicine University of Greifswald Greifswald Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Genetics (clinical),Genetics,Molecular Biology

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