Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate

Author:

Marcoux Julien12,Champion Thierry3,Colas Olivier3,Wagner-Rousset Elsa3,Corvaïa Nathalie3,Van Dorsselaer Alain12,Beck Alain3,Cianférani Sarah12

Affiliation:

1. BioOrganic Mass Spectrometry Laboratory (LSMBO), IPHC, Université de Strasbourg; 25 rue Becquerel 67087 Strasbourg France

2. IPHC, CNRS, UMR7178; 67087 Strasbourg France

3. Centre d'Immunologie Pierre-Fabre (CIPF); 5 Av. Napoléon III, BP 60497 74164 Saint-Julien-en-Genevois France

Funder

OptimAbs network bioclusters (LyonBiopole and Alsace Biovalley)

DGCIS

Oséo

Feder

Région Rhône-Alpes

Région Alsace

Communauté Urbaine de Strasbourg

CNRS

University of Strasbourg

GIS IBiSA

Synapt G2 HDMS

Exactive Plus EMR Orbitrap

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Reference45 articles.

1. Targeted cancer therapy: conferring specificity to cytotoxic drugs;Chari;Acc Chem Res,2008

2. Antibody-drug conjugates;Ornes;Proc Natl Acad Sci USA,2013

3. World antibody-drug conjugate summit, October 15-16, 2013, San Francisco, CA;Klinguer-Hamour;MAbs,2014

4. Review of antibody-drug conjugates, methods in molecular biology series: a book edited by Laurent Ducry;Beck;MAbs,2014

5. The next generation of antibody-drug conjugates comes of age;Beck;Discov Med,2010

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