Affiliation:
1. School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou 325035 China
2. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China
Abstract
The nucleophilic substitution of organohalides with alkylamines is one of the most heralded reactions in synthetic chemistry. However, the resulting halide anions are often wasted in routine workup experiments and not fully utilized. Herein, we report a halogen recycling strategy for radical aminohalogenation of maleimides with XCH2CH2X (X = Cl, Br) and alkylamines with excellent functional group compatibility. The strategy's excellent generality is demonstrated by 38 aminohalogenated products, twofold aminochlorination, and late‐stage vinylchlorination of nortriptyline.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
State Key Laboratory of Structural Chemistry
Subject
Inorganic Chemistry,General Chemistry
Cited by
3 articles.
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