A rare case of tumefactive demyelination of brain: A case report and literature review

Author:

Inban Pugazhendi1,Akuma Ogbonnaya2,Elavia Zenia3,Akuma Chinaza Mercy4,Singh Mansi5ORCID,Kachhadia Meet Popatbhai6,Musiime Agaba Barnett James7

Affiliation:

1. Department of General Medicine Government Medical College Chennai India

2. Ebonyi State University Abakaliki Nigeria

3. Dr. DY Patil Medical College Pune India

4. Nnamdi Azikiwe University Awka Nigeria

5. Bogomolets National Medical University Kyiv Ukraine

6. P.D.U Medical College, Civil Hospital Campus Rajkot India

7. Royal College of General Practitioners (RCGP) London UK

Abstract

AbstractThis case report highlights the diagnostic challenges encountered in a 30‐year‐old female presenting with fever followed by Wernicke's aphasia without right‐sided weakness, ultimately diagnosed as tumefactive demyelination (TD). TD is a rare neurological condition often misidentified as brain tumors or inflammatory disorders. The case emphasizes the importance of precise differentiation through advanced magnetic resonance imaging, showing restricted diffusion at lesion edges and the absence of gadolinium enhancement. Accurate diagnosis is crucial for tailored treatment and prognostic assessment. This case contributes to our understanding of TD and underscores the need for continued research and collaboration in the field of rare neurological disorders.

Publisher

Wiley

Subject

General Medicine

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