Affiliation:
1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry University of Science and Technology of China 230026 Hefei Anhui People's Republic of China
Abstract
AbstractThe ruthenium(II)‐catalyzed reaction of aniline derivatives with allylamines was carried out, affording 2‐methylindoles via C−H/C−N bond activation. 4,5‐Dimethyl pyrimidin‐2‐yl group attached on the nitrogen atom of anilines is the most effective directing group and N‐allyl‐4‐fluoro‐N‐methylaniline is the optimal allylamine. The cyclization products were obtained in 16% to 96% yields. The method does not require external oxidant. A possible mechanism is proposed.magnified image
Funder
National Natural Science Foundation of China
Cited by
1 articles.
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