Affiliation:
1. Institute of Organic Chemistry Jiangxi Science & Technology Normal University Key Laboratory of Organic Chemistry Nanchang 330013 People's Republic of China
2. Shaanxi Key Laboratory of Chemical Reaction Engineering College of Chemistry and Chemical Engineering Yan'an University Yan'an Shaanxi 716000 People's Republic of China
Abstract
AbstractPropargylic alcohols are regarded as a class of readily available and versatile synthons in organic synthesis. Due to their unique bifunctional character, the transformation of propargylic alcohols has been widely utilized as a powerful strategy for the construction of various functionalized frameworks over the past few decades. Recently, the radical transformation of propargylic alcohols has attracted considerable attention in synthetic chemistry. This review summarizes recent progress in the radical transformation of propargylic alcohols. Based on the different mechanisms of radical formation underlying these transformations, this review has been divided into four parts: (1) transition‐metal catalyzed radical transformation; (2) photo‐induced radical transformation; (3) electro‐induced radical transformation; and (4) metal‐free or oxidant‐mediated radical transformation of propargylic alcohols.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangxi Province
Jiangxi Science and Technology Normal University