Affiliation:
1. Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University 1023 South Shatai Road Baiyun District, Guangzhou 510515 People's Republic of China
Abstract
AbstractThis study reports the copper‐catalyzed α‐indolmethylation of 2‐pyridylacetates with 3‐indoleacetic acids. This reaction offers an approach to generating alkylideneindolenine electrophiles via the oxidative decarboxylation of 3‐indoleacetic acids. The developed reaction system demonstrates good versatility, extending beyond the indolmethylation of 2‐pyridylacetates to include activated esters and nitroalkanes. Moreover, a biological evaluation revealed that several products exhibited antiproliferative activity against different cancer cell lines.
Funder
Basic and Applied Basic Research Foundation of Guangdong Province