Fluorinated Substrates as Michael Acceptors Towards Fine Chemicals

Abstract

AbstractMichael addition reaction, known since the 19th century, appeared as a relevant method with a great potential to design new organofluorinated fine chemicals and enlarged their structural diversity. In the Michael addition reaction for the synthesis of organofluorine compounds, the fluorinated blocks can be both used as the Michael donors and acceptors, but the latter is relatively rare. This review aims to provide a comprehensive summary of the use of fluorinated substrates as Michael acceptors in Michael reactions.